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[This article belongs to Volume - 70, Issue - 1]
Published on : 2025-01-08 13:51:10
Article Code: AMJ-08-01-2025-12309
Title : Focused Ultrasound-Mediated Blood-Brain Barrier Opening Enables Amyloid-β Immunotherapy in Cerebral Amyloid Angiopathy Without Microhemorrhage Risk
Author(s) : Dr. William Chen, Dr. Fatima Al-Zahra, Dr. Robert Klein
Abstract :
Cerebral amyloid angiopathy (CAA) complicates Alzheimer's immunotherapy due to vessel-associated amyloid and
microhemorrhage risk. We employed MRI-guided focused ultrasound (FUS) with microbubbles to achieve localized,
reversible blood-brain barrier (BBB) opening in Tg-SwDI mice modeling CAA. FUS-enhanced delivery of aducanumab
resulted in 70% reduction of vascular amyloid without increased cerebral microbleeds observed in systemic high
dose regimens. Histological analysis confirmed reduced perivascular macrophage activation and preserved vascular
integrity. FUS-mediated BBB opening offers a safe, spatially targeted approach for immunotherapeutic intervention
in CAA and other vascular pathologies.