About the Article
Article Files
[This article belongs to Volume - 70, Issue - 4]
Published on : 2025-04-17 14:27:55
Article Code: AMJ-17-04-2025-12317
Title : Mitochondrial Transplantation from Induced Pluripotent Stem Cells Reverses Cellular Bioenergetic Failure in Sepsis-Induced Acute Kidney Injury
Author(s) : Dr. James Liu, Dr. Priya Sharma
Abstract :
Sepsis-associated acute kidney injury (SA-AKI) is characterized by mitochondrial dysfunction and ATP depletion. This
proof-of-concept study demonstrates that transplantation of healthy, respiration-competent mitochondria isolated
from induced pluripotent stem cell-derived renal tubular cells restores bioenergetic capacity in injured kidneys. Intra
renal arterial injection of autologous platelet-derived mitochondria coated with Pep-1 cell-penetrating peptide in a
murine cecal ligation and puncture model preserved tubular integrity, reduced oxidative stress markers, and
improved renal function biomarkers (creatinine clearance ↑ 65%). Metabolic flux analysis confirmed restoration of
oxidative phosphorylation and spare respiratory capacity. Mitochondrial transplantation emerges as a novel
cytoprotective modality for septic organ failure.