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[This article belongs to Volume - 69, Issue - 10]
Published on : 2024-10-03 13:05:24
Article Code: AMJ-03-10-2024-12302
Title : Bioprinted Vascularized Cardiac Patches Using Patient-Specific Induced Pluripotent Stem Cells for Pediatric Congenital Heart Defect Repair
Author(s) : Dr. Emily Roberts
Abstract :
Surgical repair of congenital heart defects (CHD) in neonates is limited by donor tissue availability. We bioprinted
vascularized cardiac patches using patient-specific iPSC-derived cardiomyocytes, fibroblasts, and endothelial cells
embedded in a decellularized myocardial matrix. Sacrificial Pluronic F127 channels enabled spontaneous
microvascular network formation perfusable within 7 days. Patches exhibited synchronous contraction,
electrophysiological coupling, and calcium handling comparable to native pediatric myocardium. Implantation in a
porcine model of right ventricular outflow tract repair demonstrated integration, neovascularization, and ejection
fraction preservation at 6 months. Patient-specific bioprinting offers a regenerative solution for pediatric cardiac
surgery.