About the Article
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[This article belongs to Volume - 69, Issue - 10]
Published on : 2024-10-03 13:07:34
Article Code: AMJ-03-10-2024-12303
Title : Cold Atmospheric Plasma Therapy Induces Immunogenic Cell Death in Chemoresistant Triple-Negative Breast Cancer
Author(s) : Dr. Anna Kowalski, Dr. Robert Chen
Abstract :
Triple-negative breast cancer (TNBC) lacks targeted therapies and frequently develops chemotherapy resistance. Cold
atmospheric plasma (CAP) generates reactive oxygen/nitrogen species (RONS) that selectively kill cancer cells. We
demonstrate that CAP treatment of cisplatin-resistant TNBC cell lines and patient-derived xenografts induces
immunogenic cell death (ICD), characterized by calreticulin exposure, ATP secretion, and HMGB1 release. CAP
generated RONS activated the cGAS-STING pathway, triggering type I interferon responses and dendritic cell
maturation. Combination of CAP with anti-PD-1 therapy eradicated established tumors in immunocompetent mice
through CD8+ T-cell-mediated immunity. Physical plasma medicine offers an innovative immunotherapeutic modality
for resistant TNBC.